![]() Specific PNA oligomers have been used as anticancer therapeutics to detect tumor cells or deliver small molecule drugs targeting nucleic acids 3, 4. It is easy to hybridize DNA/PNA sequences because the structure of PNA is similar to natural nucleic acid ( Figure 1). Purines and pyrimidines are then connected to the backbone by methylene carbonyl linkages 2. PNAs have a distinct N-(2-aminoethyl)glycine backbone. PNA bionanotechnology, which includes nanoparticles, nanodevices, and nanoscale phenomena within the discipline of nanotechnology, affords a new approach for scientists to create new functional materials for cancer detection and therapy. PNAs play an important role as therapeutic agents, anticancer agents, molecular tools and biosensor probes, as well as in nanotechnology. Peptide nucleic acid (PNA) was originally invented in 1991 by Peter E NIELSEN (University of Copenhagen), Michael EGHOLM (University of Copenhagen), Rolf H BERG (Risø National Laboratory), and Ole BUCHARDT (University of Copenhagen) to act as a sequence-specific DNA binding reagent 1.
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